i went from 250 to 350 and the motor mounts had to be set to the secondary set of holes. I have a th350 trans and it bolted right up....dunno if this helps or not. just my experiences
That TH350 if it is for a 250 is under-equipped to handle a small block. Factory I6 TH350 have.. I forget which parts.. but they are not made to the same durability or what have you. They have less of something inside, I know, but just letting you know in case it was the OE th350.
"the stall speed is not the only difference, the 6 cylinder units had taller pistons in the drums...that means less clutches. Forward drum has 4 ,direct has 3,"
"The 6 cylinder used lighter springs in the governer"
if your truck doesnt see HD use I would think it would be OK but nature of a V8 power delivery vs a i6 may affect things, so just be careful I guess