Here is the pattern I have found after spending almost 50 years trouble shooting electrical wiring. The large ground cable from battery to engine block, or battery to alternator on GM products, is the most important ground because it's for the starter primarily, but also supplies the ground circuit for the rest of engine functions. It is NOT a good idea to reroute the circuit by going to the frame first, then back to the engine. Lengthening the cable and adding connections is not a logical option, if it was the factory would have done it that way. Virtually all manufactures used the same configuration for a reason. The main ground always goes straight to the engine. The second ground goes from battery to frame and usually the core support. The third ground goes from back of engine to firewall. On trucks because the frame is isolated from the bed, there will be a ground connecting the frame to the body, and a ground from cab to frame. This configuration changes slightly on uni-body cars that don't have a frame. The positive and ground on a vehicle are equally important, for some reason people with little knowledge of electrical act like grounds are just an extra precaution. Adding extra grounds just shows others that you don't understand how they actually work, there is no benefit.
The best visualization I can share is this. If one of your arms or legs was a completely different size than the other, would your body work symmetrically, or would you be favored to one side? Same concept with electrical. It is not a coincidence that the electrical wires in you house, hot neutral and ground are all the same gauge. If you're not going to install a second starter in the bed of the truck and use it to grind coffee beans you do not need fat grounds anywhere else. (Except maybe to the sub amp)