There are volumes that could be written to answer your question. Short answer, yes, truck accy brackets work.
I use a 2010 Camaro waterpump and relocate the idler with a little kit from Dirty Dingo.
Engine mounting in a 4x4 is limited since relocating the transfer case is so tough. 2wd allow moving the engine forward to keep the low mounted A/C, which otherwise requires a high mount A/C bracket or relocating the right side engine stand.
The easiest fuel system is an 87+ tbi tank with a high pressure pump inside, about $300.
Radiator works fine. Exhaust is dependant on engine position. Hooker cast iron manifolds clear pretty much any situation.
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